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苯二氮(卓)类药物在慢性失眠症患者中的应用合理性与规范性分析

Rationality and Standardization Analysis of Benzodiazepines in Chronic Insomnia Patients

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目的:分析苯二氮(卓)类药物在慢性失眠症患者中的应用合理性与规范性.方法:选取 148 例 2022 年 11月~2023 年 11 月乐安县人民医院门诊的慢性失眠症患者为研究对象,收集患者电子处方资料,观察苯二氮艹卓类药物使用情况,评价苯二氮艹卓类药物使用的合理性与规范性.结果:148 例患者中 55 例使用苯二氮艹卓类药物,其中阿普唑仑片处方最多,为 48 张(32.43%),氯硝西泮片 5 张(3.38%)、地西泮片 2 张(1.35%),大多数慢性失眠患者处方为非苯二氮艹卓类药物(93 例,62.84%);苯二氮艹卓类药物用药不规范情况中以处方书写不规范居多,重复用药、用药时间过长、用药范围不适宜、配伍禁忌等情况出现较少;阿普唑仑片、氯硝西泮片、地西泮片药物利用指数(drug utilization index,DUI)均<1,药物使用具有合理性.结论:乐安县人民医院慢性失眠症患者应用苯二氮艹卓类药物治疗的整体过程具有合理性与规范性,部分不足还需进一步提升.
Objective:To analyze the rationality and standardization of benzodiazepine drugs in chronic insomnia patients.Methods:148 patients with chronic insomnia from November 2022 to November 2023 were selected,the electronic prescription data were collected,the use of benzodiazepines was observed,and the rationality and standardization of benzodiazepine use were evaluated.Results:55 of the 148 patients were on benzodiazepines,alprazolam tablets were the most prescribed,for 48 sheets(32.43%),5 clonazepam tablets(3.38%),2 diazepam tablets(1.35%).The majority of chronic insomnia patients were prescribed non-benzodiazepines(93,62.84%).In the non-standard situation of benzodiazepine drugs,the prescription writing is not standardized.Repeated drug use,too long drug use time,inappropriate scope of drug use,incompatibility and other conditions appear less.Drug utilization index(DUI)of alprazolam tablets,clonazepam tablets and diazepam tablets were<1,Drug use is justified.Conclusion:The overall process of benzodiazepine treatment for chronic insomnia patients in our hospital is reasonable and normative,and some deficiencies need to be further improved.

benzodiazepinechronic insomniarationalitynormative

黄俊华

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乐安县人民医院,抚州,344300,中国

苯二氮艹卓类药物 慢性失眠症 合理性 规范性

江西省自然科学基金资助项目

20224BAB216088

2024

神经药理学报
河北北方学院 中国药理学会

神经药理学报

影响因子:0.283
ISSN:2095-1396
年,卷(期):2024.14(4)