Sedative effect of dexmedetomidine on patients undergoing mechanical ventilation com-bined with blood purification and its impact on respiratory mechanics
Objective To explore the sedative effect of dexmedetomidine on ICU patients undergoing mechanical ventilation combined with blood purification and its impact on respiratory mechanics.Method Fifty ICU patients who re-ceived mechanical ventilation combined with blood purification treatment at Zhoushan Hospital in Zhejiang Province from January 2021 to December 2022 were randomly divided into a dexmedetomidine group and a midazolam group using a ran-dom number table method,with 25 patients in each group.The dexmedetomidine group and midazolam group were given sedative treatment with dexmedetomidine and midazolam,respectively.At the same time,both groups were given sufentanil analgesic treatment.The sedative effect,clinical related indicators,hemodynamic indicators,respiratory mechanics indicators,and incidence of adverse events were compared between the two groups.Results There was no statistically significant dif-ference in the satisfaction rate of sedation and the time to achieve satisfactory sedation effect between the two groups(P＞0.05);The ICU hospitalization time,mechanical ventilation time,and wakefulness time after discontinuation of the dexmedetomidine group were shorter than those of the midazolam group,and the dosage of sufentanil was lower than that of the midazolam group(P＜0.05);The MAP and HR of the dexmedetomidine group after 1 hour of sedation were lower than those of the mida-zolam group during the same period(P＜0.05);The Cdyn and WOBp in the dexmedetomidine group were higher than those in the midazolam group,while Ppeak and Pplat were lower than those in the midazolam group(P＜0.05);There was no statisti-cally significant difference in the incidence of adverse events between the two groups(P＞0.05).Conclusion For ICU pa-tients undergoing mechanical ventilation combined with blood purification,the use of dexmedetomidine sedation can achieve satisfactory results and improve hemodynamic and respiratory status without increasing the incidence of adverse events.
万方数据
维普
