The current situation of multi-drug resistant bacteria infection in patients with acquired brain injury and its influence on brain function
Objective To investigate the infection characteristics of multidrug resistant bacteria on admission of pa-tients with acquired brain injury in the rehabilitation department and analyze their effect on function.Methods Retrospec-tively investigated hospitalized patients with acquired brain injury rehabilitation in the The First Affiliated Hospital of Zhe-jiang Chinese Medical University from June 2021 to May 2023,recorded multiple infection at admission,divided patients into MDRO and non-MDRO groups,and performed functional assessment through Glasgow Coma Scale(GCS),Barthel Index(BI)at admission and discharge.Results A total of 334 patients were enrolled(133 female,201 male),including 96 MDRO pa-tients(MDRO group)and 238 non-MDRO patients(non-MDRO group).A total of 204 microbial specimens were collected from 96 patients in the MDRO group,respectively from sputum(152/204,74.5% ),urine(46/204,22.5%),and wound se-cretions(6/204,2.9%).CRE was the main MDRO type,and the top three pathogens were Pseudomonas aeruginosa,Kleb-siella pneumoniae,and Acinetobacter baumannii.The results of functional scale scores in both groups showed that the degree of functional impairment in the MDRO group was significantly higher than that in the non-MDRO group(P<0.01),and the GCS and Barthel index at discharge in both groups improved significantly(P<0.01).Conclusion This study found that 28.7% of patients with acquired brain injury in the rehabilitation department had multiple drug-resistant bacterial infection on admission,mainly derived from respiratory infections,the most dominant MDRO type was CRE,and their functional out-comes were significantly lower than that of uninfected patients.Therefore,on the basis of MDRO prevention and control,en-sure the rehabilitation treatment effect of MDRO patients,so as to improve the functional prognosis of patients.
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