Objective This study aims to evaluate and compare the efficacy of Cobas s201,Panther and ChiTaS BSS 1200/PreNAT II's nucleic acid testing(NAT)systems in detecting blood donations in Wenzhou.Methods This study includ-ed 586970 blood samples collected from blood donors in Zhejiang Province,Wenzhou from January 2018 to May 2023,and detected by Cobas s201,Panther and ChiTaS BSS1200/PreNAT II nucleic acid detection systems.The three systems adopt different detection modes:the Cobas s201 system adopts a 6-sample detection mode;the Panther system adopts a single detection mode;and the ChiTaS BSS1200/PreNAT II system adopts an 8-sample/single detection mode.Results The posi-tive detection rates of the three systems of Cobas s201,Panther and ChiTaS BSS1200/PreNAT II are:0.90‰(344/381919),3.54‰(440/124303)and 2.59‰(209/80748),and the positive detection rate of Panther is significantly higher,Compared with the other two systems(P<0.05);NAT-positive cases in Wenzhou area were mainly due to HBV infection,and the infec-tion rate was 1.22‰(717/586970);among the 42 HBV-positive specimens tested by NAT,they were mainly occult infec-tions.Conclusion The results of this study show that the three nucleic acid screening systems,Cobas s201,Panther and ChiTaS BSS1200/PreNAT II,can effectively detect nucleic acid-positive samples in enzyme immunoassay non-reactive blood samples from voluntary blood donors in Wenzhou,thereby reducing missed detections in ELISA testing.The Panther system showed a high positive detection rate,demonstrating its testing superiority in the region.In addition,NAT testing has a sig-nificant role in detecting occult HBV infection,which is of great significance in preventing transfusion-transmitted diseases.Therefore,regular analysis of test data,combined with the rational application of NAT detection systems,can further reduce the risk of transfusion-related infectious diseases.
维普
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