Clinical efficacy of different doses of triphenylphenol combined with progesterone in the treatment of threatened miscarriage in early pregnancy
Objective To investigate the clinical efficacy of different doses of triphenylphenol combined with proges-terone in the treatment of threatened miscarriage in early pregnancy.Method 367 pregnant women with threatened miscar-riage in early pregnancy from January 2021 to December 2022 were selected from the First People's Hospital of Chun'an County,Hangzhou City,Zhejiang Province.They were randomly divided into a progesterone group of 122 cases(using proges-terone alone),an observation group of 122 cases(using progesterone combined with phloroglucinol 40mg/time,once a day),and an observation group of 123 cases(using progesterone combined with phloroglucinol 40mg/time,twice a day).Compare the improvement of clinical symptoms(disappearance time of clinical symptoms(vaginal bleeding,abdominal pain or uterine contractions),number of clinical symptom recurrence cases and inevitable miscarriage cases),clinical efficacy and adverse reactions among three groups.Results In terms of clinical symptom improvement,the disappearance time of clinical symp-toms of threatened miscarriage gradually shortened in the progesterone group,observation group A,and observation group B(P＜0.01).The recurrence rate of clinical symptoms was lower in observation group A than in the progesterone group(P＜0.05),and lower in observation group B than in observation group A(P＜0.05).There was no statistically significant differ-ence in the incidence of inevitable miscarriage among the three groups(P＞0.05).In terms of clinical efficacy,the total effec-tive rate of observation group A and observation group B was significantly higher than that of progesterone group(P＜0.05),and there was no statistically significant difference between observation group A and observation group B(P＞0.05).In terms of drug safety,there was no statistically significant difference in the incidence of rash,dizziness,headache,and abnormal liv-er function among the three groups(P＞0.05).Conclusion The combination of triphenylphenol and progesterone can improve the treatment effect of threatened miscarriage in early pregnancy.The application regimen of 40mg/time,twice a day of triph-enylphenol is more helpful in rapidly improving clinical symptoms.
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