Effect of humidified high-flow nasal cannula on pulmonary function,activity and risk of AECOPD in patients with COPD and chronic hypoxemia
Objective To investigate the effects of humidified high-flow nasal cannula(HFNC)on lung function,daily activity and risk of AECOPD in patients with chronic hypoxemia.Method A total of 188 patients with long-term oxy-gen therapy who underwent COPD with hypoxemia from February 2021 to August 2022 were enrolled in the hospital.Accord-ing to the random number table,they were divided into HFNC group and control group,94 cases each;HFNC group Receiv-ing humidification and high-flow nasal catheter oxygen(oxygen flow:15～20L/min),the control group received conventional low-flow oxygen(oxygen flow:1～3L/min);After 1 year of follow-up,the lung function indexes of the patients were measured at 1,3,9 and 12 months after the start of therapy.The quality of life of the patients was scored by St George's Respiratory Questionnaire(SGRQ).The Difficult Score(modified MRC)scored the patient's dyspnea,and the 6-min walk test(6MWT)was used to evaluate the patient's mobility;the two groups were recorded for acute exacerbation of COPD 1 year before and 1 year after study(AECOPD)Number of hospitalizations.Result(1)Pulmonary function index:Forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC in the HFNC group from the third month of the study and the FVC index was superior to the control group,and the difference was statistically significant(P<0.05);At 9 months and 12 months of follow-up,the difference of PaO2 and PaCO2 in HFNC group was statistically significant(P<0.05).(2)Living abili-ty:The mMRC score was lower in the HFNC group than in the control group in the third month(P<0.05);at the 9th and 12th months,the SGRQ score,6MWT and PaCO2 in the HFNC group were superior to the control group(P<0.05);(3)AECOPD risk:There was no significant difference in the number of AECOPD hospitalizations between the two groups in the first year of the study(P>0.05).The number of hospitalizations in the HFNC group was lower than the control group(P<0.05);at the same time,the risk of AECOPD in the HFNC group was lower than that of the control group(χ2=14.42,P<0.05).Conclusion Humidification with high-flow nasal cannula can significantly improve the lung function of patients requiring long-term oxy-gen therapy,improve the quality of life,and reduce the risk of AECOPD.
COPDhigh flow oxygen inhalationnasal cannulaquality of lifeAECOPD
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