Diagnostic value of musculoskeletal ultrasound in patients with gout:A meta—analysis
Objective Musculoskeletal ultrasound(MSUS)is widely used in diagnosing gout,but its accuracy is de-batable.This study conducted a meta-analysis to quantitatively evaluate the value of ultrasound in the diagnosis of gout.Method Clinical trial literature on MSUS diagnosis of gout were collected from PubMed,Embase,Web of science,Cochrane Library,CNKI,Wanfang and VIP databases up to January 2023 after systematic search.The heterogeneity test and quality evaluation were performed on the literature.The effect size was combined and the receiver operating characteristic curve was drawn for comprehensive analysis.A subgroup analysis was conducted on the basis of the total number of joints checked and professions of the doctors.Result In total,18 studies including 1434 patients with gout,and 1236 controls were available for this meta-analysis.The pooled sensitivity according to the double contour sign was 0.74,specificity was 0.86,positive likelihood ratio was 4.85,negative likelihood ratio was 0.30,diagnostic odds ratio was 19.55,area under the curve was 0.8752,and Cochran Q index was 0.8057.Subgroup analysis showed that there were no significant changes in sensitivity and specificity when increasing the number of joints examined(≤5 joints vs.>5 joints),or when rheumatologists and sonographers examined and diagnosed jointly.Conclusion This meta-analysis of published studies demonstrates that MSUS offers good diagnostic accuracy with high sensitivity and specificity and can play an important part in the diagnosis of gout.
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