Analysis of influencing factors of diabetes insipidus after neuroendoscopic transnasosphenoidal surgery for pituitary adenoma
Objective To explore the factors influencing diabetes insipidus(DI)after neuroendoscopic transnaso-sphenoidal surgery for pituitary adenoma.Methods A total of 89 patients who underwent pituitary adenoma resection by neuroendoscopic transnasosphenoidal approach from January 2021 to June 2022 at the Affiliated Hospital of Xuzhou Medical University were selected as research objects,including 63 patients in DI group where DI occurred within three days after surgery,and 26 patients in non-DI group without DI after surgery.The two groups were compared in terms of tumor diameter,mode of tumor growth,Knosp classification of the tumor,MRI parameters(the changes of cephalocaudal tumor cavity diameter and the changes of distance from pituitary to saddle bottom before and after surgery)and other clinical data.A multivariate logistic regression analysis was performed to determine the influencing factors of occurrence of DI after surgery.Results The DI group was significantly higher than the non-DI group in proportions of tumor diameter＞3 cm,suprasellar growth of the tumor,levels 3-4 in Knosp classification,presence of preoperative visual impairment,and intraoperative cerebrospinal fluid leak,proportion of intraoperative non-removal of the pseudocapsule,changes of cephalocaudal tumor cavity diameter,and changes of the distance from pituitary to saddle bottom,the differences of which were statistically significant(all P＜0.05).The changes of cephalocaudal tumor cavity diameter(OR=0.497)and the distance from pituitary to saddle bottom(OR=2.886)were the independent influencing factors of occurrence of DI after surgery(both P＜0.05).Conclusion The changes of cephalocaudal tumor cavity diameter and the distance from pituitary to saddle bottom are factors independently influencing the occurrence of DI after neuroendoscopic transnasosphenoidal surgery for pituitary adenoma.
Pituitary adenomaDiabetes insipidusNeuroendoscopyCephalocaudal tumor cavity diameterDistance from pituitary to saddle bottom
万方数据
维普
