首页|不同认知障碍程度和疗效青少年抑郁症患者miR-381-3p、miR-124检测的临床意义

不同认知障碍程度和疗效青少年抑郁症患者miR-381-3p、miR-124检测的临床意义

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目的 探讨不同认知障碍程度和疗效的青少年抑郁症患者miR-381-3p、miR-124检测的临床意义.方法 选取2020年1月至2022年4月绍兴市第七人民医院收治的86例青少年抑郁症患者为研究对象,其中存在认知障碍31例,包括轻度14例、中度12例和重度5例;无认知障碍55例.所有患者接受心理干预、认知疗法、重复经颅磁刺激疗法联合草酸艾司西酞普兰、奥氮平口服治疗3个月,治疗前采用简易精神状态检查量表评估认知障碍程度,并检测miR-381-3p、miR-124相对表达量;治疗3个月后采用汉密尔顿焦虑量表和汉密尔顿抑郁量表评估疗效.比较认知障碍组与无认知障碍组、不同程度认知障碍以及不同疗效患者miR-381-3p、miR-124相对表达量,采用ROC曲线分析miR-381-3p、miR-124单独或联合检测对临床疗效的预测效能.结果 认知障碍组患者miR-381-3p相对表达量明显低于无认知障碍组(P<0.05),miR-124相对表达量则明显高于无认知障碍组(P<0.05).不同程度认知障碍患者miR-381-3p、miR-124相对表达量比较,差异均有统计学意义(均P<0.05),其中miR-381-3p相对表达量为轻度>中度>重度(均P<0.05),miR-124相对表达量为重度>中度>轻度(均P<0.05).治疗3个月后疗效良好66例,疗效不佳20例.疗效不佳组miR-381-3p相对表达量明显低于疗效良好组(P<0.05),miR-124相对表达量则明显高于疗效良好组(P<0.05).miR-381-3p、miR-124单独预测患者临床疗效的AUC分别为0.719、0.695,两者联合预测的AUC为0.782,两者联合检测的效能明显高于单独检测(均P<0.05).结论 miR-381-3p与miR-124联合检测有助于青少年抑郁症患者认知障碍严重程度的评估和临床疗效预测.
Clinical significance of miR-381-3p and miR-124 detection for depressive adolescents with different degrees of cognitive im-pairment and therapeutic effect
Objective To explore the clinical significance of miR-381-3p and miR-124 detection for depressive adolescents with different degrees of cognitive impairment and therapeutic effect.Methods A total of 86 adolescent patients with depression admitted to the Shaoxing Seventh People's Hospital from January 2020 to April 2022 were selected as the study subjects.Among them,there were 31 cases of cognitive dysfunction before treatment,including 14 mild cases,12 moderate cases and 5 severe cases,and 55 cases of non-cognitive dysfunctions.All of them received psychological intervention,cognitive therapy,and repeated transcranial magnetic stimulation therapy combined with Escitalopram oxalate and olanzapine oral treatment for 3 months.Before treatment,their degrees of cognitive dysfunction were assessed with the simple mental state checklist,and the relative expression levels of miR-381-3p and miR-124 were detected.After 3 months of treatment,Hamilton anxiety rating scale and Hamilton depression scale were used to evaluate the efficacy.The relative expression levels of miR-381-3p and miR-124 were compared between the cognitive dysfunction and non-cognitive dysfunction groups,and between patients with different degrees of cognitive dysfunction and different therapeutic effects.ROC curve was used to analyze the predictive efficacy of miR-381-3p and miR-124 alone or in combination.Results The relative expression level of miR-381-3p in the cognitive dysfunction group was significantly lower than that of the group without cognitive dysfunction(P<0.05),while the relative expression level of miR-124 was significantly higher(P<0.05).The relative expression levels of miR-381-3p and miR-124 in patients with different degrees of cognitive dysfunction were statistically significantly different(all P<0.05),of which,the relative expression levels of miR-381-3p were mild>moderate>severe(all P<0.05),while that of miR-124 was severe>moderate>mild(all P<0.05).After 3 months of treatment,66 cases showed good curative effect,while 20 cases received poor efficacy.The relative expression level of miR-381-3p in the poor treatment group was significantly lower than that of the good treatment group(P<0.05),while the relative expression level of miR-124 was significantly higher(P<0.05).The AUC of miR-381-3p and miR-124 independently predicting the clinical efficacy was 0.719 and 0.695,respectively,while the AUC of the combined detection was 0.782,indicating that the efficacy of the combined detection was significantly higher than that of the single detection(both P<0.05).Conclusion The combined detection of miR-381-3p and miR-124 is helpful to evaluate the severity of cognitive impairment and predict the clinical efficacy of adolescents with depression.

miR-381-3pmiR-124AdolescentDepressionCognitive impairmentClinical effect

杨振国、陈秀芳、曹世林、汪斌、褚睿、郑春美

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312000 绍兴市第七人民医院心身障碍科

浙江省台州医院儿科

miR-381-3p miR-124 青少年 抑郁症 认知障碍 临床疗效

浙江省医药卫生科技计划项目

2019KY231

2024

浙江医学
浙江省医学会

浙江医学

CSTPCD
影响因子:0.428
ISSN:1006-2785
年,卷(期):2024.46(1)
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