Application of pharyngeal volume combined with minimal nasal cross-sectional area in early screening of adult non-obese ob-structive sleep apnea hypopnea syndrome
Objective To explore the application value of pharyngeal volume combined with minimal nasal cross-sectional area(mCSA)in early screening of adult non-obese obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Seventy-five adult non-obese patients with OSAHS diagnosed by polysomnography(PSG)in Jinhua Municipal Centeral Hospital from January to June 2023 were selected as the observation group,while 50 healthy volunteers matched in gender,age,and BMI were selected as the control group.The pharyngeal parameters(including minimal cross-sectional area and volume of palatopharyngeal and glossopharyngeal cavities)and mCSA during calm breathing and Muller breathing were examined by using 256 slice spiral CT and post reconstruction technology.The clinical data,pharyngeal parameters,and mCSA were compared between the two groups,and Spearman analysis was used to examine the correlation between pharyngeal parameters,mCSA,and PSG parameters.ROC curve was used to evaluate the efficacy of glossopharyngeal volume and mCSA alone or in combination in diagnosis of adult non-obese OSAHS.Results The proportions of rhinitis and hypertension,and Epworth sleepiness scale(ESS)score in the observation group were higher than those of the control group(all P＜0.01).The minimal cross-sectional area and volume of the palatopharyngeal and glossopharyngeal cavities,as well as mCSA value during Muller breathing in the observation group were significantly less than the control group(all P＜O.01).Spearman test showed that in the observation group,glossopharyngeal volume and mCSA values at Muller breathing phase were significantly negatively correlated with apnea hypopnea index and the lowest arterial oxygen saturation(all P＜0.05),and were significantly positively correlated with the percentage of time when blood oxygen saturation was below 90％(both P＜0.01).The receiver operating curve(ROC)showed that the area under the curve(AUC)of glossopharyngeal volume and mCSA values alone or in combination at Muller breathing phase for diagnosing adult non-obese OSAHS were 0.831,0.743,and 0.878,respectively;the efficacy of combined diagnosis was significantly higher than single indicator(both P＜0.05).Conclusion CT measurement of pharyngeal volume and mCSA can be used as non-invasive indicators for early screening and diagnosis of adult non-obese OSAHS,and the combined diagnosis shows good potential.
万方数据
维普
