Application of artificial intelligence assisted systems in the study of cervical thinprep fluid-based cytology
Objective To explore the application of artificial intelligence(Al)assisted diagnostic systems in cervical thinprep fluid-based cytology research.Methods Cervical thinprep fluid-based cytological smear samples of 1 994 cases in Huzhou Maternal & Child Health Care Hospital were collected from July 2022 to February 2023.With grades 1 or above in vaginal biopsy results of cervical intraepithelial lesions(≥ CIN 1+)as the gold standard,three methods were used to read cervical thinprep fluid-based cytology smears:manual reading,artificial Al reading,and Al assisted system reading(Al assisted reading).Statistical methods were used to compare the differences in the positive rates detected by the three reading methods among different age groups,and to compare the sensitivity,specificity,and time needed for reading among the three reading methods,so as to explore the diagnostic efficiency of the Al assisted system in cervical fluid-based cytology research.Results Out of 1 994 samples,102 showed ≥ CIN 1+results in colposcopy biopsy,with an overall positive rate of 5.12％.The positive rate for atypical squamous cells of undetermined significance and above(≥ ASC-US)in cervical thinprep fluid-based cytologic test(TCT)was 9.63％,while that for low-grade squamous intraepithelial lesion and above(≥ LSIL)in TCT was 4.91％.When the TCT results were ≥ ASC-US,the positive rate by Al reading among patients aged ≥ 30 years was significantly higher than that of the 18-29 age groups(P＜0.05),while the positive rate by manual reading or Al assisted reading showed no differences between the two age groups(both P＞0.05).When the TCT results were ≥ LSIL,the positive rate via the three reading methods showed no statistical differences between age groups of 18-29 and ≥ 30 years(all P＞0.05).When the TCT results were ≥ ASC-US,the sensitivity and specificity of manual reading were 100.00％and 95.30％,respectively,while those of Al assisted reading were 95.10％and 94.66％,respectively.No statistical differences were observed in the sensitivity and specificity of the two reading methods(both P＞0.05).When TCT results were ≥ LSIL,the sensitivity and specificity of manual reading were 66.67％and 98.78％,respectively,while those of Al assisted reading were 82.35％and 97.15％,respectively.A statistical difference in sensitivity was observed between the two methods of reading(P＜0.05),while there was no statistical difference in specificity(P＞0.05).Compared with manual reading,the total reading time of Al assisted reading was reduced by 25.34 hours,and 50.76％(25.34/49.92);the average length of each smear decreased by 45.75 s,and the average reading time decreased by 50.77％(45.75/90.12).Conclusion Pathologists can use Al assisted systems to screen for cervical cancer,ensuring the accuracy of reading and improving the efficiency of cytological reading.
万方数据
维普
