Drug resistance analysis of carbapenem-resistant Klebsiella pneumoniae clinical isolates
Objective To analyze the distribution and drug resistance of carbapenem-resistant Klebsiella pneumoniae(CRKP)clinical isolates.Methods Clinical specimens were collected for bacterial culture from patients admitted to Wenling First People's Hospital from January 2018 to December 2020.A total 907 strains of Klebsiella pneumoniae were isolated,of which 295 were carbapenem-resistant strains.The isolated CRKP strains were subjected to drug sensitivity test and further confirmed.Results The most of CRKP strains were isolated from sputum samples(227 strains,77.0％),followed by urine samples(9.5％),pus samples(5.4％),and blood samples(3.4％).Among all CRKP isolates,117 strains were from the department of critical care medicine(39.7％),followed by the department of respiratory medicine(10.9％),rehabilitation(8.8％),infection(6.4％),and neurosurgery(6.4％).Drug resistance analysis showed that the resistance rates of tigecycline,amikacin,and trimethoprim-sulfamethoxazole were less than 40.0％,and the resistance rates of other antibiotics were more than 60.0％.Conclusion This study shows that the drug resistance of CRKP is high in the hospital.It is necessary to strengthen the monitoring,optimize the medication strategy,and adjust the usage and dosage of antibiotics in time to reduce the rate of drug resistance.
万方数据
维普
