Clinicopathologic features for residual lesions after cervical conization of HPV-associated endocervical adenocarcinoma with non-destructive growth
Objective To evaluate the clinicopathologic features of residual lesions in HPV-associated endocervical adenocarcinoma with non-destructive growth after cervical conization.Methods Sixty-two cases of HPV-associated endocervical adenocar-cinoma with non-destructive growth undergoing cervical conization at Shaoxing Maternal and Children Health Hospital from January 2018 to December 2022 were enrolled in the study.Residual lesions were found in 13 cases during the follow-up,and the clinicopathological features between the residual group(n=13)and the non-residual group(n=49)were compared and the risk factors of residual lesions were analyzed.Results Among 62 patients there were 38 cases of adenocarcinoma in situ(AIS)and 24 cases of Silva A type adenocarcinoma with a mean age of(44.9±9.2)years(25-68).All cases were in FIGO stage I A with no recurrence or metastasis during the follow-up period.There were significant differences between AIS and Silva A type adenocarcinoma in lesion range and quadrant distribution(both P＜0.05).The residual lesion after cervical conization was associated with the age of patients(＞45 years old),the positive margin of conization,the multi-quadrant distribution of lesions,and the positive results of endocervical curettage during conization(all P＜0.05).Conclusion HPV-associated AIS and Silva type A adenocarcinomas may be at different stages of endocervical adenocarcinoma with non-destructive growth and good prognosis,however,residual lesions may occur in patients with various risk factors.The study indicates that hysterectomy is recommended for patients without fertility requirements,while for patients without risk factors it is advised to develop a personalized program to avoid overtreatment.
HPV-associatedEndocervical adenocarcinoma with non-destructive growthConizationResidue lesions
万方数据
维普
