Association between serum TARC,vWF levels and severity of psoriasis vulgaris patients
Objective To investigate the association between serum thymus activation regulated chemokines(TARC),von Willebrand factor(vWF)levels and the disease severity in patients with psoriasis vulgaris(PV).Methods Seventy four PV patients treated at the Cangzhou People's Hospital from February 2020 to February 2022 were enrolled as PV group,and 42 healthy subjects were taken as the control group.According to the severity of disease patients were divided into mild to moderate group(40 cases)and severe group(34 cases).Serum TARC,vWF,TNF-α,IL-8 levels were measured with ELISA and compared among patients with different severity of disease.Pearson correlation analysis was used to analyze the correlation between serum TARC,vWF and clinical indexes in PV patients.Multiple logistic regression analysis was conducted to analyze the risk factors of severe PV disease;and the value of risk factors in predicting disease severity was analyzed by ROC curve.Results The serum TARC and vWF in PV group were significantly higher than those in control group(P＜0.05).Serum TARC,vWF,WBC,neutrophil counts,ESR,psoriasis area and severity index(PASI),hypersensitive C-reactive protein(hs-CRP),TNF-α,IL-8 in severe PV group were significantly higher than those in mild to moderate group(all P＜0.05).The serum TARC,vWF levels were positively correlated with ESR,hs-CRP,PASI score,TNF-α and IL-8 in PV group(all P＜0.05).Elevated serum TARC and vWF were independent risk factors of severe PV disease.The AUC of the combined detection of serum TARC and vWF was 0.903,which was significantly higher than that of TARC and vWF alone(0.823,0.807,P＜0.05).The sensitivity and specificity of serum TARC and vWF in combination to predict the severity of PV disease were 0.878 and 0.753,respectively.Conclusion The levels of serum TARC and vWF in PV patients increase,which are positively correlated with the severity of PV.The combination of serum TARC and vWF can be used to evaluate the severity of PV disease.
万方数据
维普
