Study on the value of hysteroscopy in GnRHa-HRT endometrial preparation protocol in frozen-thawed embryo transfer
Objective To explore the value of hysteroscopy(HS)in gonadotropin releasing hormone agonist-hormone replacement therapy(GnRHa-HRT)endometrial preparation protocol in frozen-thawed embryo transfer(FET).Methods A total of 112 infertile women who had undergone one or two failed embryo transfer(ET)cycles at the Reproductive Center of Jiaxing City Maternal and Child Health Hospital from January 2022 to October 2022 were randomly assigned to GnRHa-HRT group(n=56)and GnRHa-HS-HRT group(n=56).The general data of patients and clinical outcome of FET were compared between the two groups.Results There were no statistically significant differences between the two groups in the patients'age,duration of infertility,body mass index(BMI),the number of previously failed embryo transfer,endometrial thickness on the day of conversion,the number of transferred embryos,the number of transferred good-quality embryos,the number of transferred good-quality blastocyst,and type and factor of infertility(all P＞0.05).There were also no statistically significant differences between the two groups in the rates of biochemical pregnancy,clinical pregnancy,spontaneous miscarriage,ectopic pregnancy and live births(all P＞0.05);however,implantation rate was higher in GnRHa-HS-HRT group than in GnRHa-HRT group(40.20％vs.26.47％,x2=4.324,P=0.038);there were 56 patients in the GnRH-HS-HRT group underwent HS,and the HS results were normal in 26 patients(46.43％)and abnormal in 30 patients(53.57％).No statistically significant differences were observed in the rates of biochemical pregnancy,clinical pregnancy,implantation,spontaneous miscarriage,ectopic pregnancy and live births between the normal and abnormal groups(all P＞0.05).Conclusion There is a high incidence of intrauterine abnormalities in patients with embryo transfer failures;HS combined with uterine cavity scratching is conducive to the detection of uterine microscopic lesions and the improvement of endometrial receptivity.FET and HS can be performed concurrently within the same menstrual cycle,which can shorten total treatment time,and improve pregnancy outcomes.
万方数据
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