Multiparameter magnetic resonance imaging in differentiating low-risk and high-risk prostate cancer
Objective To investigate the differences of intravoxel incoherent motion diffusion weighted imaging(IVIM-DWI)parameters and diffusion kurtosis imaging(DKI)parameters in differentiating low-risk and high-risk prostate cancer(PCa).Methods The clinical and imaging data of 49 patients with PCa confirmed by pathology admitted in the First Affiliated Hospital of Zhejiang Chinese Medical University from January to December 2018 were retrospectively analyzed,including 13 patients with low-risk PCa(Gleason score≤3+4)and 36 patients with high-risk PCa(Gleason score≥4+3).All patients underwent routine prostate MRI,IVIM-DWI and DKI sequence scanning.The prostate cancer region of interest(PCa-ROI)was delineated and its apparent diffusion coefficient(ADC value)was measured.The IVIM main parameters included molecular diffusion coefficient(D),perfusion-related diffusion coefficient(D*),perfusion fraction(f);the DKI main parameters included mean diffusivity(MD)and mean kurtosis(MK).Independent sample test was used to compare the differences of various parameters between low-risk group and high-risk group.The receiver operating characteristic curve(ROC)was used to analyze the efficiency of various parameters in differentiating low-risk and high-risk PCa.Results The ADC,D,D*,f,MD and MK value of low-risk group were 0.654±0.125,0.355±0.142,18.700(4.290,48.300),0.421±0.143,1.914±0.506 and 0.791±0.206 respectively;while those of high-risk group were 0.550±0.118,0.382±0.115,11.600(5.363,29.950),0.332±0.137,1.496±0.502 and 0.946±0.196 respectively.There were significant differences in ADC,MD and MK values between high-and low-risk groups(all P＜0.05),while there were no significant differences in D,D*and f between two groups(all P＞0.05).When ADC,MD and MK value were used to differentiate low-risk and high-risk PCa,the AUC were 0.732,0.739 and 0.750 respectively,the diagnostic sensitivity was 0.692,0.769 and 0.639;and the diagnostic specificity was 0.750,0.728 and 0.846 respectively.Conclusion The conventional ADC value has certain application value in differentiating low-risk and high-risk PCa,while some DKI parameters also have the same effect,which may provide supplement measurements.
Diffusion kurtosis imagingIntravoxel incoherent motion diffusion weighted imagingProstate cancer
万方数据
维普
