Relationship between erythrocyte sedimentation rate and albumin ratio and disease activity in patients with ankylosing spondylitis
Objective To investigate the relationship between erythrocyte sedimentation rate(EAR)and albumin ratio(ALB)and disease activity in patients with ankylosing spondylitis(AS).Methods A total of 298 AS patients hospitalized in the Department of Rheumatology and Immunology,Guangdong Second Provincial General Hospital from January 2016 to September 2021 were selected as the observation group.Among them,patients with Bath Ankylosing Spondylitis Disease Activity Index(BASDAI)≥4 were assigned to active subgroup(111 cases)and those with BASDAI＜4 were assigned to the inactive subgroup(187 cases).Another 85 healthy subjects receiving health examination in the same hospital were selected as the control group.The laboratory test indexes of the two groups were collected,and the disease activity of AS was determined by Bath Ankylosing Spondylitis Functional Index(BASFI)and BASDAI.Spearman rank correlation analysis was used to observe the correlation between laboratory test indicators and disease activity in the observation group.Logistic regression analysis was used to evaluate the risk factors for disease activity of AS patients.ROC curve was used to evaluate the relative value of risk factors for disease activity of AS patients.Results In active subgroup,neutrophil to ALB ratio(NAR),platelets to ALB ratio(PAR),CRP,ESR,EAR and BASFI were higher than those of the inactive subgroup,and ALB was lower than that of inactive subgroup(all P＜0.05).EAR was positively correlated with BASDAI and BASFI(rs=0.213,0.329,both P＜0.001).According to binary logistic regression analysis,EAR was an independent indicator of disease activity of AS patients(OR=1.018,95％CI:1.001-1.034,P=0.035).The AUC of the EAR(0.613,95％CI:0.548-0.678)was higher than that of PLR,MLR,NAR,and PAR.The optimal cut-off value of EAR for AS in active subgroup was 0.85,and the sensitivity and specificity were 0.568 and 0.652,respectively.Conclusion The level of EAR in patients with active AS is high and is positively correlated with the disease activity of AS.The EAR is a promising biomarker for assessing disease activity of patients with AS.
Ankylosing spondylitisDisease activityErythrocyte sedimentation rate to Albumin ratio
万方数据
维普
