Predictive efficiency of plasma platelet activating factor levels on vascular reocclusion after intravenous thrombolysis for acute ce-rebral infarction
Objective To analyze the predictive efficiency of plasma platelet activating factor(PAF)levels on vascular reocclusion after intravenous thrombolysis for patients with acute cerebral infarction.Methods A total of 276 patients with acute cerebral infarction,who were hospitalized at Department of Neurology,Wenzhou Central Hospital between January 2019 and June 2022 and underwent intravenous thrombolysis using recombinant tissue plasminogen activator,were selected.Among which,61 patients with vascular reocclusion after intravenous thrombolysis were assigned into the observation group and another 215 patients without vascular reocclusion were assigned into the control group.All patients'general data,National Institutes of Health Stroke Scale(NIHSS)scores,infarction locations and so on were collected and compared.Plasma PAF levels at admission were measured.Multivariate analysis was used to analyze the independent predictors of vascular reocclusion after intravenous thrombolysis;a prediction model was constructed,a nomogram was plotted,and the ROC curve was built to compare the predictive efficiencies on vascular reocclusion after intravenous thrombolysis between plasma PAF levels and the prediction model.Results Patients in the observation group had significantly higher BMI,NIHSS scores,percentage of post-circulation cerebral infarction,blood glucose levels and plasma PAF levels than those in the control group,and the differences were statistically significant(all P＜0.05).The logistic regression analysis showed that NIHSS scores(OR=1.373,95％CI:1.137-1.658),post-circulation cerebral infarction(OR=1.008,95％CI:1.001-1.015)and plasma PAF levels(OR=1.006,95％CI:1.002-1.010)all were influential factors of vascular reocclusion after intravenous thrombolysis(all P＜0.05).AUC of plasma PAF levels for predicting vascular reocclusion after intravenous thrombolysis was 0.725(95％CI:0.632-0.778;P＜0.001),with an optimal cutoff value of 221.50 ng/mL,sensitivity of 0.739 and specificity of 0.688.AUC of the prediction model for predicting vascular reocclusion after intravenous thrombosis was 0.816(95％CI:0.748-0.874;P＜O.001).Conclusion Higher plasma PAF level may be an independent predictor of vascular reocclusion after intravenous thrombolysis for patients with acute cerebral infarction,which shows high predictive efficiency for vascular reocclusion after intravenous thrombolysis.
万方数据
维普
