Analysis on the occurrence and influencing factors of major adverse cardiovascular events in patients with coronary heart dis-ease combined with heart failure
Objective To analyze the occurrence and influencing factors of major adverse cardiac events(MACEs)in patients with coronary heart disease combined with heart failure.Methods Clinical data of 366 patients with coronary heart disease combined with heart failure admitted to the Department of Cardiology of Lishui Central Hospital from March 2020 to August 2022 were selected.Among them,102 cases with MACE were assigned to the observation group and another 264 cases without MACE were assigned to the control group according to 1-year follow-up results.The general data,serum parameters[cardiac troponin Ⅰ(cTnⅠ),N terminal B-type brain natriuretic peptide(NT-proBNP),C-reactive protein(CRP)]and left ventricular ejection fraction(LVEF)were compared between the two groups.ROC curve was used to analyze the predictive efficacy of serum cTnⅠ,NT-proBNP and CRP on 1-year MACE in patients with both coronary heart disease and heart failure.Multivariate logistic regression was used to analyze the risk factors for 1-year MACE of patients.Results The proportion of patients graded Ⅲ-Ⅳ in the New York Heart Association(NYHA)heart function grading,and cTnⅠ,NT proBNP,and CRP levels in the observation group were all higher than those of the control group,and the differences were statistically significant(all P＜0.05).Serum cTnⅠ,NT proBNP,and CRP can all be used to predict 1-year MACE of patients with both coronary heart disease and heart failure.Multivariate logistic regression analysis showed that NYHA heart function grades Ⅲ-Ⅳ,cTnⅠ ≥0.51 ng/mL,NT proBNP ≥3617.46 pg/mL,and CRP ≥6.43 mg/L were all risk factors for 1-year MACE of patients(P＜0.05).Conclusion There are many factors that affect the occurrence of 1-year MACE in patients with both coronary heart disease and heart failure.Among them,close attention should be paid to NYHA heart function grades Ⅲ-Ⅳ,cTnⅠ,NT-proBNP,CRP and other indicators,and relevant prevention and treatment measures should be taken as soon as possible to improve patient prognosis.
Coronary heart diseaseHeart failureAdverse cardiovascular eventsCardiac troponinC-reactive protein
万方数据
维普
