Relationship between different glucose metabolism states and cerebral small vessel disease burden and the influencing factors of cerebral small vessel disease burden
Objective To analyze the relationship between different glucose metabolism states and cerebral small vessel disease burden,and the influencing factors of cerebral small vessel disease burden.Methods A total of 281 patients with dizziness who were admitted to the Department of Neurology of Shaoxing Second Hospital Medical Community General Hospital from January 2017 to June 2021 were selected,and they were divided into normal glucose regulation(NGR)group with 113 cases,impaired glucose regulation(IGR)group with 96 cases,and type 2 diabetes mellitus(T2DM)newly-diagnosed group with 72 cases according to the blood glucose test results.Their general clinical data,blood glucose and related test indicators were collected,cerebral small vessel disease burden was evaluated,and then they were divided into the low burden group with 203 cases and the high burden group with 78 cases.Cerebral small vessel disease burden of the three groups with different glucose metabolism states,and the clinical characteristics of the low and high burden groups of cerebral small vessel disease were compared.The related factors influencing cerebral small vessel disease burden were analyzed by multivariate logistics regression.Results There were statistically significant differences in BMI and cerebral small vessel disease burden between NGR,IGR and T2DM newly-diagnosed groups(all P＜0.05).The age,BMI,fasting plasma glucose(FPG),glycated hemoglobin A1C(HbA1C)and creatinine in the low burden group were significantly lower than those in the high burden group(P＜0.05).Multivariate logistics regression analysis showed that BMI,FPG and HbA1C were the influencing factors of cerebral small vessel disease burden(P＜0.05).Conclusion Different glucose metabolism states are related to cerebral small vessel disease burden.FPG,HbA1C and obesity are influencing factors of cerebral small vessel disease.
Type 2 diabetes mellitusCerebral small vessel diseaseBurdenRelationship
万方数据
维普
