Value of CT perfusion in predicting clinical outcome of early endovascular treatment for acute ischemic stroke with large ischemic core
Objective To explore the predictive value of CT perfusion in the early endovascular treatment of acute ischemic stroke with large ischemic core.Methods Fifty-four acute ischemic stroke patients with large ischemic core underwent early endovascular treatment in Zhejiang Provincial People's Hospital from October 2018 to November 2022 were enrolled.According to the modified Rankin scale(mRS)score 90 days after operation,the patients were divided into good outcomes group(n=23)and poor outcomes group(n=31).The general clinical data and CT perfusion imaging of the two groups were collected and compared.Multivariate logistic regression analysis was used to explore the correlation between CT perfusion imaging and clinical outcomes of endovascular treatment for acute ischemic stroke with large ischemic core.ROC curve was used to analyze the value of CT perfusion imaging in predicting the prognosis of endovascular treatment for acute ischemic stroke with large ischemic core.Results NIHSS score in the observation group was lower than that of the control group,and the mismatch rate in observation group was significantly compared with the control group(both P＜0.05).Multivariate logistic regression analysis showed that NIHSS score and mismatch rate were independently associated with good outcomes of endovascular treatment for acute ischemic stroke with large ischemic core(both P＜0.05).The ROC curve showed that the AUC of mismatch rate for predicting good outcomes of endovascular treatment for acute ischemic stroke with large ischemic core was 0.660(95％CI:0.509-0.811,P=0.046),with the optimal cutoff value of 2.30,the sensitivity of 0.696,and the specificity of 0.645.Conclusion CT perfusion imaging is closely related to the clinical outcomes of endovascular treatment for acute ischemic stroke with large ischemic core,and may be predictive for good clinical outcomes.
Large ischemic coreCT perfusionEarly endovascular therapyClinical outcome
万方数据
维普
