Objective To investigate the value of peripheral blood inflammation indices in predicting the occurrence and prognosis of retinal vein occlusion(RVO)macular edema(ME)(RVO-ME).Methods Sixty patients with RVO-ME(RVO group)visiting the First Affiliated Hospital of Zhejiang Chinese Medical University from October 2021 to October 2022 were enrolled in this prospective study;and 60 age and sex-matched patients undergoing cataract or refractory surgery were recruited as control group.The RVO group received 3 months successive treatment of Lucentis.The baseline inflammation indexes of peripheral blood were measured and compared between RVO-ME and control groups.After 3 months treatment,the inflammation indexes were compared between patients with remained ME and those without ME in RVO-ME groups.Receiver operator characteristic curve(ROC)was used to evaluate the efficiency of inflammation indices in predicting the development and prognosis of RVO-ME.Results Compared to control group,RVO group presented significantly higher systemic immune inflammatory index(SII),neutrophil-to-lymphocyte ratio(NLR),and mean platelet volume-to-lymphocyte ratio(MPVLR)(all P＜0.05).After 3 months treatment,only Sil showed significant descending in RVO group(P＜0.05).After 3 months treatment,there was significant difference in WBC between patients with remained ME and those without ME(P＜0.05)ROC analysis showed that NLR was superior to other inflammatory indices to predict RVO-ME,and the optimal cut-off value was 2.17 with a sensitivity of 0.621 and a specificity of 0.672,respectively.The optimal cut-off value for WBC in predicting prognosis of RVO-ME was 6.25x109/L with a sensitivity of 0.690 and a specificity of 0.595.Conclusion Values of SI I,NLR and MPVLR rise in acute phase.NLR is a more promising index for RVO-ME development prediction;and sustained high WBC value may indicate a poor prognosis of RVO-ME.
维普
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