Inflammation indexes for predicting occurrence and prognosis of retinal vein occlusion macular edema
Objective To investigate the value of peripheral blood inflammation indices in predicting the occurrence and prognosis of retinal vein occlusion(RVO)macular edema(ME)(RVO-ME).Methods Sixty patients with RVO-ME(RVO group)visiting the First Affiliated Hospital of Zhejiang Chinese Medical University from October 2021 to October 2022 were enrolled in this prospective study;and 60 age and sex-matched patients undergoing cataract or refractory surgery were recruited as control group.The RVO group received 3 months successive treatment of Lucentis.The baseline inflammation indexes of peripheral blood were measured and compared between RVO-ME and control groups.After 3 months treatment,the inflammation indexes were compared between patients with remained ME and those without ME in RVO-ME groups.Receiver operator characteristic curve(ROC)was used to evaluate the efficiency of inflammation indices in predicting the development and prognosis of RVO-ME.Results Compared to control group,RVO group presented significantly higher systemic immune inflammatory index(SII),neutrophil-to-lymphocyte ratio(NLR),and mean platelet volume-to-lymphocyte ratio(MPVLR)(all P＜0.05).After 3 months treatment,only Sil showed significant descending in RVO group(P＜0.05).After 3 months treatment,there was significant difference in WBC between patients with remained ME and those without ME(P＜0.05)ROC analysis showed that NLR was superior to other inflammatory indices to predict RVO-ME,and the optimal cut-off value was 2.17 with a sensitivity of 0.621 and a specificity of 0.672,respectively.The optimal cut-off value for WBC in predicting prognosis of RVO-ME was 6.25x109/L with a sensitivity of 0.690 and a specificity of 0.595.Conclusion Values of SI I,NLR and MPVLR rise in acute phase.NLR is a more promising index for RVO-ME development prediction;and sustained high WBC value may indicate a poor prognosis of RVO-ME.
万方数据
维普
