Application of inflammatory indexes in diagnosis of early diabetic kidney disease
Objective To explore the value of inflammatory indexes in the diagnosis of early diabetes kidney disease(DKD).Methods Three hundred patients with type 2 diabetes(T2DM)diagnosed in Lishui People's Hospital from August 2019 to August 2021 were enrolled in the study,including 100 cases without DKD(simple DKD group),100 cases of DKD with microalbuminuria(early DKD group)and 100 cases of DKD massive albuminuria(severe DKD group);50 sex and age-matched healthy subjects were selected as the control group.The serum inflammatory indexes and urine indexes were compared among groups.The risk factors of early DKD were analyzed with multivariate logistic regression;the association between inflammatory indexes and renal injury related indexes was examined with Spearman rank correlation;the diagnostic efficacy of inflammatory indexes for early DKD was evaluated with ROC curve.Results Serum CRP,TNF-α and IL-6 levels in DKD patients were significantly higher than those in the control group;the levels of above indicators in early and severe DKD groups were significantly higher than those in simple DKD group(all P＜0.05),while there was no statistically significant difference between early and severe DKD groups(all P＞0.05).Multivariate logistic regression analysis showed that urinary N-acetyl-β-D-glucosamine glycosidase and β2-microglobulin(β2-MG),serum TG,CRP and IL-6 were independent risk factors of DKD(all P＜0.05),and serum CRP,IL-6 were positively correlated with urinary β2-MG(all P＜0.05).The area under ROC curve(AUC)of CRP,IL-6,β2-MG and the combination of three for diagnosis of early DKD was 0.714,0.769,0.785 and 0.862 respectively.Conclusion The combination of serum CRP,IL-6 and urinary β2-MG levels has high application value in the early diagnosis of DKD.
万方数据
维普
