Association of serum levels of oxidative stress factors with anxiety symptoms in patients with generalized anxiety disorder
Objective To explore the association of serum levels of oxidative stress factors with anxiety symptoms in patients with generalized anxiety disorder(GAD).Methods One hundred and one patients with GAD in Huzhou Third Municipal People's Hospital from January 2022 to January 2023(GAD group)and 100 healthy subjects(control group)were enrolled in the study.The serum levels of malondialdehyde(MDA),superoxide dismutase(SOD),high density lipoprotein(HDL),glutathione peroxidase(GSH-Px),catalase(CAT),cortisol,nitric oxide(NO),and lipid peroxide(LPO),oxidative stress factors were determined by ELISA.Hamilton anxiety scale(HAMA)scores were measured to evaluate the degree of anxiety;and Hamilton depression scale-17(HAMD-17)scores were measured to evaluate the degree of depression in all subjects.Results The levels of MDA,cortisol,LPO,HAMA score and HAMD-17 score in GAD group were significantly higher than those in control group(all P＜0.05);while SOD,GSH-Px and CAT levels in GAD group were significantly lower than those in control group(all P＜0.05).There were no-significant differences in HDL and NO between the two groups(both P＞0.05).The levels of MDA,NO and LPO in GAD group were positively correlated with HAMA scores(all P＜0.05),while SOD and GSH-Px were negatively correlated with HAMA scores(both P＜0.05)in GAD patients.The regression model revealed that elevated MDA level is a risk factor for the onset of GAD(P＜0.05).Conclusion GAD patients have oxidative stress imbalance,and elevated MDA is a risk factor for the onset of GAD.
万方数据
维普
