Significance of prognostic nutritional index in evaluating the prognosis of patients after radical surgery for gastric cancer
Objective To explore the significance of dynamic changes of prognostic nutritional index(PNI)in evaluating prognosis of gastric cancer patients after radical gastrectomy.Methods Clinical data were collected from 178 patients confirmed with gastric cancer by pathological examination and received radical surgery at the Affiliated Hospital of Xuzhou Medical University from January 2015 to June 2017.ROC curves were used to determine the optimal cutoff values for preoperative(PNI1)and postoperative(PNI2)prognostic nutritional indices,and patients were grouped accordingly.Kaplan-Meier survival analysis was employed to evaluate disease-free survival and overall survival among different groups.Cox regression analysis was utilized to analyze factors influencing patient prognosis.Results The optimal cutoff value for PNI1 was 48.95,and for PNI2 was 46.85.Patients were categorized into three groups based on the optimal cutoff values:Group A(PNI1＞48.95 and PNI2＞46.85),[Group B1(PNI1≤48.95 and PNI2＞46.85),Group B2(PNI1＞48.95 and PNI2≤46.85)],and Group C(PNI1≤48.95 and PNI2≤46.85).The 5-year disease-free survival rates for the three groups were 82.2％,39.6％,and 7.2％,respectively,while the 5-year overall survival rates were 88.9％,60.2％,and 32.0％,respectively.Cox multivariate analysis revealed that PNI was an independent factor influencing the prognosis of patients after radical surgery for gastric cancer.Conclusion Constructing a PNI scoring system combining preoperative and postoperative PNls has higher efficacy in predicting the prognosis of patients after radical gastrectomy for gastric cancer,providing a reference for clinical treatment and improvement of patient prognosis.
万方数据
维普
