Efficacy and risk factors of ultrasound-guided drug injection in the treatment of knee osteoarthritis
Objective To analyze the efficacy and risk factors of ultrasound-guided drug injection in the treatment of knee osteoarthritis.Methods From October 2023 to March 2024,80 patients with knee osteoarthritis treated with ultrasound-guided drug injection were selected from Chinese People's Liberation Army 63680 Unit Hospital.Comparative analysis was conducted on the clinical data of patients who were divided into a cured group(61 cases)and an uncured group(19 cases)after recovery.Univariate and multivariate logistic regression analyses were used to identify the risk factors affecting treatment efficacy;An ROC chart was drawn to evaluate the clinical indicators that predict efficacy.Results There were statistically significant differences in age,course of disease,BMI,hyperuricemia,knee surgery history,trauma history,CRP,IL-6,WBC,and knee Lysholm scores between the two groups of patients(all P<0.05);The results of multivariate logistic analysis showed that age,BMI,course of disease,CRP,IL-6,and WBC were independent risk factors affecting treatment efficacy(OR=1.151,1.220,4.354,1.635,1.056,1.330,all P<0.05).Among the independent risk factors,course of disease showed the highest OR than other risk factors,and it was strongly correlated with the treatment efficacy.ROC curve showed that CRP had the best predictive efficacy in predicting curative effect(AUC=0.801),with higher sensitivity(0.842)and specificity(0.864)than other clinical indicators(all P<0.05).Conclusion Age,BMI,course of disease,CRP,IL-6,and WBC are independent risk factors that affect the efficacy of ultrasound-guided drug injection therapy in the treatment of knee osteoarthritis,among which,course of disease is strongly associated with efficacy.CRP can accurately evaluate the efficacy of ultrasound-guided drug injection therapy in the treatment of knee arthritis.