Objective To analyze the serum carbohydrate antigen 72-4(CA72-4)levels in gout patients and explore its relationship with blood uric acid levels.Methods One hundred and twenty gout patients who were treated at the 903rd Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from January 2020 to December 2022 were selected as the gout group.Another 52 healthy individuals who came to the hospital for physical examination during the same period were selected as the control group.The fasting elbow vein blood was collected from the two groups in the morning,serum CA724 levels were measured using electrochemiluminescence,and blood uric acid levels were measured using a fully automated biochemical analyzer.The serum levels of CA72-4 and uric acid were compared between the gout group and the control group;The correlation between serum CA72-4 levels and blood uric acid in patients with gout,and the risk factors for gout were analyzed.Results The serum CA72-4 and uric acid levels of the gout group were both higher than those of the control group[(5.76±1.39)U/mL ratio(1.21±0.37)U/mL,(748.29±75.41)μmol/L ratio(321.20±34.52)μmol/L,and the differences were statistically significant(all P＜0.05).Pearson correlation analysis showed a positive correlation between serum CA72-4 levels and uric acid in patients with gout(r=0.572,P＜0.05).Multivariate logistic regression analysis showed that high serum levels of CA724,uric acid,ESR,and high sensitivity C-reactive protein(hs-CRP)were all risk factors for gout(all P＜0.05).Conclusion The serum CA72-4 level in gout patients is significantly elevated and positively correlated with blood uric acid levels.The serum CA72-4 level may serve as an auxiliary indicator for early diagnosis of gout patients.
维普
万方数据
