Predictive value of 3D power Doppler ultrasonography in histological grading of breast cancer
Objective The aim of the study was to investigate the diagnostic and predictive value of vascular quantitative parameters in three-dimensional power Doppler ultrasonography(3D-PDUS)for histological grading of breast cancer.Methods In this retrospective observational study,77 breast cancer patients(with 86 malignant masses)underwent surgery in Hangzhou Hospital of Traditional Chinese Medicine January 2018 to June 2023 were included.All masses were confirmed by histopathological examination,and divided into grades Ⅰ,Ⅱ,and Ⅲ groups accordingly.Age,conventional ultrasonoscopy and 3D-PDUS measures of patients were compared among the three groups using Kruskal-Wallis H test,Pearson's chi-squared test or Fisher exact test.Among which,conventional ultrasonoscopy included lymph node metastasis,internal calcification of mass and mass Adler grading;3D-PDUS measures included mass volume,and vascular parameters[vascularization index(VI),flow index(FI),vascularity flow index(VFI)].The risk factors for histological grading of breast cancer were analyzed by Oridinal logistics regression.ROC curve was used to compare the accuracy of VI,FI and VFI in predicting histological grade.Results Vascular parameter values of VI,FI,and VFI in grade Ⅲ group were higher than those of grade Ⅱ group,followed by the grade Ⅰ group,with statistical significance(all P＜0.05).Among the parameters,FI was an independent risk factor for different histological grades of breast cancer(P＜0.001).ROC curve analysis showed that VI,FI and VFI all had high accuracy in predicting pathological grade(AUC=0.888,0.891,and 0.894,respectively,all P＜0.001).Conclusion VI,FI and VFI are important quantitative index of intratumoral vascularization evaluated by 3D-PDUS,which could provide more reliable prediction diagnostic information for the histological grading of breast cancer.
3D power Doppler ultrasonographyBreast cancerHistological gradingUltrasoundPathology
万方数据
维普
