Diabetes course,24 h-UPr and β-CTX for predicting diabetic retinopathy in patients with type 2 diabetes mellitus
Objective To investigate risk factors of diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM),and their predictive value.Methods A total of 356 T2DM patients admitted in the Endocrinology Department of the Second Affiliated Hospital of Wenzhou Medical University from January 2020 to December 2021 were enrolled,including cases complicated with diabetic retinopathy(DR group)and cases without retinopathy(NDR group)based on fundus color imaging results.The baseline data,related biochemical indicators,bone turnover markers and cytokines of the two groups were compared.The multivariate logistic regression analysis was used to analyze the related factors of DR,and the ROC curve was used to evaluate the predictive value of risk factors for DR.Results The course of diabetes,systolic blood pressure,24-hour urinary protein(24 h-UPr),serum creatinine,serum urea nitrogen,endogenous creatinine clearance,cystatin C,urine β2 microglobulin,β-CTX,N-MIDoc and 25-hydroxyvitamin D were significantly associated with DR in T2DM patients(all P＜0.05).Multivariate logistic regression analysis showed that β-CTX(OR=0.997,P＜0.01)was a protective factor,while the duration of diabetes(OR=1.118,P＜0.01),24 h-UPr(OR=3.431,P＜0.05)were risk factors for DR in T2DM.The area under ROC curve(AUC)of the duration of diabetes combined with 24 h-UPr and β-CTX for predicting DR was 0.769;taking 8.5 years,0.135 g/24 h and 500 μg/mL as the optimal cut off values respectively,the sensitivity and specificity of the combination of 3 indicators were 0.701 and 0.696,respectively.Conclusion The lower β-CTX level,the longer course of diabetes and the higher 24 h-UPr level are independent risk factors for DR in T2DM patients,and the combination of three indicators has a certain diagnostic value for DR.
Type 2 diabetes mellitusDiabetic retinopathy24-hour urinary proteinCourse of diabetes[3-carboxyl terminal peptide
万方数据
维普
