Monitoring of sensory gating P50 in patients with childhood-onset schizophrenia during rehabilitation
Objective To investigate sensory gating P50 in patients with childhood-onset schizophrenia(COS)during rehabilitation.Methods Fifty-nine COS patients treated in Jiaxing First Hospital,Shanghai Mental Health Center and Shanghai Changning District Mental Health Center from February 2017 to September 2020 were enrolled,and 38 healthy children were selected as controls.P50 was detected using the stimulation sequence S1 and S2 paradigms in all subjects.The effects of COS children were followed up after 3 years of treatment,and P50 indexes were compared between the two groups before treatment,including S1-P50 latency and amplitude,S2-P50 latency and amplitude,and the ratio of S2-P50 to S1-P50 amplitude(S2/S1).The correlation between P50 indexex of central zero(Cz)and positive and negative syndrome scale(PANSS)score in COS children was analyzed,and the P50 indexes of Cz before and 1,2 and 3 years after treatment in COS children were compared.Results The effective rate in COS patients was 71.2％after 3 years of risperidone treatment.Compared with the control group,S2-P50 amplitude and S2/S1 in frontal zero,parietal zero and Cz brain regions were higher in COS group(all P＜0.05).There were no significant differences in S1-P50 latency and amplitude,S2-P50 latency in three brain regions between two groups(all P＞0.05).The five P50 indexes in Cz brain region of COS children were positively correlated with PANSS activating factor scores(all P＜0.05),but no correlation was found with PANSS total score and other subscale scores(all P＞0.05).There were no significant differences in S1-P50 latency and amplitude,S2-P50 latency and amplitude,and S2/S1 in Cz brain region at multiple time points before and after COS treatment(all P＞0.05).Conclusion COS patients have P50 defects.P50 variation during 3-year follow-up may be the biological status marker of COS in this group.
SchizophreniaChildrenFeeling door controlFollow up
万方数据
维普
