Eight-year trajectories of thyroid function and prolactin levels in long-term hospitalized patients with schizophrenia
Objective To analyze the eight-year trajectories of thyroid function and prolactin(PRL)levels in long-term hospitalized patients with schizophrenia.Methods A total of 105 patients with schizophrenia who were hospitalized in Shenzhen Kangning Hospital from January 2014 to September 2022 were enrolled.The visit frequency was once a year,with a total follow-up period of 8 years.At the end of each year,the average values of thyroid function indicators,including thyroid-stimulating hormone(TSH),T3,T4,FT3,FT4,and PRL were documented,and the average value of each index was taken as the record value.The analysis of repeated measurements with mixed-model was applied to identify the 8-year trajectories of the thyroid function indicators and PRL levels.The interaction between thyroid function indicators and the dose of antipsychotic drugs,and between the types of antipsychotic drugs and PRL were further analyzed.Results Compared with the baseline data,TSH level was higher at the end of 2th to 8th year(all P＜0.05);T3 decreased first and then increased,it was lower at the end of the 2nd year(P＜0.05)and higher at the end of the 7th and 8th year(both P＜0.01);T4 level was lower at the end of 5th and 7th year(both P＜0.01);FT3 was higher at the end of the 1st to 4th year and the end of the 7th and 8th year(all P＜0.01);FT4 was higher at the end of 1st to 8th year(all P＜0.01).There was no significant difference in PRL levels at the end of 1st to 8th year(all P＞0.05).Compared with females,male patients had lower level of TSH at the end of 6th year(P＜0.05),lower level of T3 at the end of 7th year(P＜0.05),lower level of T4 at the end of 8th year(P＜0.01),and higher FT3 at the end of 7th and 8th year(both P＜0.05),lower level of PRL at the end of 1st to 3rd year and the end of 7th year(all P＜0.05).There was an interaction between T3,PRL and the dose of antipsychotic agents(equal dose of olazine)(both P＜0.05),and between PRL and the dose of aripiprazole,amisulpride,risperidone,clozapine,sulpiride(all P＜0.01).Conclusion Long-term hospitalized patients with schizophrenia exhibit sustained and significant changes in thyroid function over an 8-year follow-up period.While the changes of prolactin level are not noticeable,prolactin levels are correlated to gender,dosage,and type of antipsychotic drugs.
万方数据
维普
