Objective To explore the causal relationship between BMI and chronic skin ulcer(CSU)based on two sample mendelian randomization(TSMR).Methods Instrumental variables strongly associated with BMI were screened out through the genome-wide association study,and CSU data were selected from the FinnGen database.The causal relationship between BMI and CSU was analyzed using TSMR.The MR-Egger and inverse variance weighted(IVW)were used to test the heterogeneity,and the MR-Egger was used to test the horizontal pleiotropy.Results A total of 334 single nucleotide polymorphisms were analyzed by TSMR.IVW and Weighted median showed that BMI increased the risk of CSU(OR=1.638,1.860,both P＜0.01).However,the results of MR-Egger,Simple mode,and Weighted mode were not significant(all P＞0.05).There was no heterogeneity or horizontal pleiotropy in all the data(all P＞0.05),suggesting that the data were robust and reliable.Conclusion TSMR analysis indicates that elevated BMI may increase the risk of CSU.
Mendelian randomizationChronic skin ulcerBody mass indexCausality
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