Causal relationship between BMI and chronic skin ulcer based on two sample mendelian randomization
Objective To explore the causal relationship between BMI and chronic skin ulcer(CSU)based on two sample mendelian randomization(TSMR).Methods Instrumental variables strongly associated with BMI were screened out through the genome-wide association study,and CSU data were selected from the FinnGen database.The causal relationship between BMI and CSU was analyzed using TSMR.The MR-Egger and inverse variance weighted(IVW)were used to test the heterogeneity,and the MR-Egger was used to test the horizontal pleiotropy.Results A total of 334 single nucleotide polymorphisms were analyzed by TSMR.IVW and Weighted median showed that BMI increased the risk of CSU(OR=1.638,1.860,both P＜0.01).However,the results of MR-Egger,Simple mode,and Weighted mode were not significant(all P＞0.05).There was no heterogeneity or horizontal pleiotropy in all the data(all P＞0.05),suggesting that the data were robust and reliable.Conclusion TSMR analysis indicates that elevated BMI may increase the risk of CSU.
Mendelian randomizationChronic skin ulcerBody mass indexCausality
万方数据
维普
