Effect of prophylactic anticoagulation on symptomatic venous thromboembolism after radiofrequency closure of the great sa-phenous vein
Objective To investigate the effect of prophylactic anticoagulants on symptomatic venous thromboembo-lism(VTE)after radiofrequency closure of the great saphenous vein.Methods A total of 1 074 patients who underwent radiofrequency closure of the great saphenous vein in the Department of Vascular Surgery of Zhejiang Provincial People's Hospital from January 2022 to December 2022 were retrospectively selected as the study objects.Among them,106 patients did not receive prophylactic anticoagulant therapy(no-anticoagulantion group),762 patients received 10 mg rivaroxaban for 5 d(5-d anticoagulation group),and 206 patients received 10 mg rivaroxaban for 10 d(10-d anticoagulation group).The incidence of VTE and hemorrhagic events within 1 month after surgery were compared among the 3 groups.Results No VTE occured within 1 month after surgery in the no-anticoagulantion group,while the incidence of VTE within 1 month after surgery in the 5-d and 10-d anticoagulantion group was 0.52％(4/762)and 0.49％(1/206).There was no statistically significant difference in the incidence of VTE within 1 month after surgery among the 3 groups(P=0.593).No hemorrhagic events occured within 1 month after surgery in the no-anticoagulantion group and the 5-d anticoagulantion group.One case of hematuria occured in the 10-d anticoagulantion,with an incidence of 0.49％(1/206).There was no statistically significant difference in the incidence of hemorrhagic events with 1 month after surgery among the 3 groups(P=0.191).Conclusion Prophylactic anticoagulantion with rivaroxaban after radiofrequency closure of the great saphenous vein may not significantly reduce the incidence of VTE,but it may not increase the risk of hemorrhage.
Varicose great saphenous veinRadiofrequency closure of the great saphenous veinRivaroxabanVenous thromboembolism
万方数据
维普
