Contrast-enhanced ultrasound features of hepatocellular carcinoma and their relationship with clinical staging and microvascu-lar invasion
Objective To investigate the contrast-enhanced ultrasound features of hepatocellular carcinoma(HCC),and their relationship with clinical staging and microvascular invasion(MVI).Methods The medical records of 125 patients with pathologically confirmed HCC in Quzhou Hospital of Zhejiang Medical and Health Group from January 2022 to January 2023 were retrospectively reviewed.All patients underwent contrast-enhanced ultrasonography.The time-signal intensity curve(TIC)parameters were compared between focal area and liver parenchyma;and the correlation of TIC parameters with clinical stage and MVI in HCC patients was analyzed.Results The time to peak,duration,and wash-out time in HCC were significantly shorter,the peak intensity was significantly higher than those in liver parenchyma(all P＜0.05).There were significant differences in duration,clearance time and peak intensity between stage Ⅰ,Ⅱ and Ⅲ HCC,and the duration and wash-out time in stage Ⅰ and stage Ⅱ HCC were significantly longer,the peak intensity was significantly lower than those in stage Ⅲ HCC(all P＜0.05).The duration and wash-out time in stage Ⅰ HCC were significantly longer,while the peak intensity was significantly lower than those in stage Ⅱ HCC(all P＜0.05).The duration and wash-out time of patients with positive MVI were significantly shorter,and the peak intensity was significantly higher than those with negative MVI(all P＜0.05).In MVI positive patients,the duration and clearance time of the stage Ⅱ patients(n=33)were significantly higher,while the peak intensity was lower than those of stage Ⅲ patients(n=17)(all P＜0.05).In patients with negative MVI,the duration and clearance time of the stage Ⅰ group(n=61)were significantly higher,while the peak intensity was lower than those of the stage Ⅱ patients(n=14)(all P＜0.05).Spearman correlation analysis found that the time to peak,duration and wash-out time of contrast-enhanced ultrasound were negatively correlated with clinical stage,and peak intensity was positively correlated with clinical stage in HCC patients(all P＜0.05).The time to peak,duration and wash-out time of contrast-enhanced ultrasound were negatively correlated with MVI positivity,and peak intensity was positively correlated with MVI positivity in HCC patients(all P＜0.05).Conclusion The contrast-enhanced ultrasound features of HCC patients are correlated to clinical stage and MVI,which provides information for clinical staging and MVI evaluation.
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