Diagnostic significance of high-sensitivity C-reactive protein,procalcitonin and endotoxin in infectious diseases
Objective To explore the diagnostic significance of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)and endotoxin(ET)in infectious diseases.Methods A total of 196 inpatients admitted to Hangzhou Cancer Hospital from December 2021 to November 2022 were retrospectively selected.According to the infection situation,they were divided into systemic infection group(n=10),local infection group(n=67)and uninfected group(n=119).The gender,age,primary disease and department information of the three groups of patients were compared,the levels of hs-CRP,PCT and ET in the three groups were detected and compared,and the correlation analysis was conducted among hs-CRP,PCT and ET.Results There were statistically significant differences in the primary disease and departments among the three groups(both P＜0.05).Among which,the proportion of malignant tumor patients in the local infection group was higher than that of the uninfected group,and the difference was statistically significant(P＜0.05).In the systemic infection group,the proportion of patients in the intensive care unit was higher than that of the local infection group and the uninfected group,with the proportion in the local infection group higher than that of the uninfected group(all P＜0.05).Compared with local infection group and uninfected group,the levels of hs-CRP and PCT in systemic infection group were significantly increased,and the differences were statistically significant(all P＜0.05).The level of ET in systemic infection group was higher than that of the non-infection group(P＜0.05).The patients'blood hs-CRP was positively correlated with PCT(P＜0.01).Conclusion The detection of blood hs-CRP and PCT has a certain significance in the diagnosis of systemic infection in hospitalized patients.Clinical attention should be paid to the infection of patients with malignant tumors and critically ill patients,and the treatment plan should be adjusted timely and reasonably.
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