Effect of subcutaneous immunotherapy with standardized allergens on children with allergic rhinitis complicated with cough vari-ant asthma
Objective To observe the efficacy of subcutaneous immunotherapy(SCIT)with standardized allergen in the treatment of children with allergic rhinitis combined with cough variant asthma(CVA).Methods Seventy-six children with allergic rhinitis complicated with CVA admitted to the First People's Hospital of Chun'an County from September 2021 to December 2022 were retrospectively selected.Among them,38 patients were treated with standardized allergen SCIT as the observation group,while the other 38 patients were treated with conventional symptomatic medication alone as the control group.The efficacy and adverse reactions(including oral pruritus,gastrointestinal discomfort,urticaria,eye conjunctival hemorrhage,dyspnea,etc.)were observed and compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(94.74％vs.76.32％,P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation and control groups(15.79％vs.18.42％,P＞0.05).Conclusion Standardized allergen SCIT can significantly improve rhinitis and asthma symptoms in children with allergic rhinitis complicated with CVA,which shows certain safety.
Subcutaneous immunotherapy with standardized allergenAllergic rhinitisCough variant asthmaInflamma-tory factor
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