Analysis on factors influencing the severity grading of white matter hyperintensities in HIV-infected patients
Objective To analyze the factors affecting the severity grading of white matter hyperintensities(WMH)in the brains of HIV-infected patients.Methods A total of 176 HIV-infected patients diagnosed and underwent brain MRI examination at the Hangzhou Xixi Hospital affiliated to Zhejiang Chinese Medical University from January 2016 to December 2022 were collected and divided into three groups according to different WMH severity grades:129 cases in grade Ⅰ,35 cases in grade Ⅱ,and 12 cases in grade Ⅲ.The distribution of WMH in patients was observed and recorded,and the general clinical data and various laboratory examination data of the three groups of patients were compared to analyze the factors affecting the grading of WMH.Results WMH in most HIV-infected patients were found to coexist in the periventricular and deep brain regions,followed by the deep brain region.The incidence rate of WMH was 88.64％in the deep brain,while 68.75％in the periventricular region.There were statistically significant differences in TG and the duration of combined antiretroviral therapy(cART)treatment among the three groups(both P＜0.05).The results of the multifactorial logistic regression analysis showed that the duration of cART treatment(OR=1.007,95％CI:1.000-1.015,P=0.047)was an independent risk factor for the grading of WMH severity in HIV-infected patients.Conclusion WMH is more likely to occur in the deep brain region than in the periventricular region of HIV-infected patients;the duration of cART treatment is an independent risk factor affecting the grading of WMH in HIV-infected patients and may increase the risk of cerebral small vessel disease in HIV-infected patients.
万方数据
维普
