Effect of intrauterine perfusion of granulocyte-colony stimulating factor on pregnancy outcome of patients with thin endome-trium undergoing frozen-thawed embryo transfer
Objective To investigate the effect of intrauterine perfusion with granulocyte colony-stimulating factor(G-CSF)on pregnancy outcomes in women with thin endometrium undergoing frozen-thawed embryo transfer(FET).Methods In this retrospective cohort study,132 women with thin endometrium undergoing frozen-thawed embryo transfer cycles in Reproductive Medicine Center of Huzhou Maternity & Child Health Care Hospital from January 2017 to October 2023 were enrolled,including 76 cases receiving intrauterine infusion of G-CSF before the day of administration of pro-gesterone(G-CSF group),and 56 patients without G-CSF treatment(control group).The general data of patients and pregnancy outcome of FET were compared between the two groups;endometrial thickness was compared before and after intrauterine perfusion;and multivariate modified Poisson regression was used to analyze the influencing factors of clinical pregnancy.Results In G-CSF group,the endometrial thickness was significantly increased from(5.4±0.9)mm to(7.6±0.9)mm(P＜0.05)after G-CSF perfusion.The embryo implantation rate and clinical pregnancy rate in the G-CSF group were significantly higher than those in the control group(40.0％vs.30.3％,52.6％vs.33.9％,both P＜0.05);and the early miscarriage rate was on a downward trend,but there was no statistical difference between the two groups(25.0％vs.31.6％,P＞0.05).Multivariate modified Poisson regression analysis suggested that the intrauterine perfusion of G-CSF had no significant impact on clinical pregnancy rate after adjusting confounding factors(RR=1.217,95％CI:0.615-2.410,P＞0.05).Conclusion In patients with thin endometrium,intrauterine perfusion of G-CSF can be considered to increase the end-ometrium thickness for FET to improve the clinical pregnancy rate and implantation rate.
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