Analysis on bile acid metabolism and sex hormone levels of patients with polycystic ovary syndrome
Objective To analyze the characteristics of bile acid metabolism in patients with polycystic ovary syndrome(PCOS)and explore its relationship with sex hormone levels.Methods Fifty-four PCOS patients(PCOS group)who underwent health examination in Xuzhou Maternal and Child Health Hospital from January to June 2023 were selected,while another 53 healthy females who underwent health examination during the same period were selected as the control group.On the 2-5 days of menstruation,fasting elbow venous blood was collected in the morning to detect the levels of sex hormones and bile acid metabolites.The levels of serum sex hormones and bile acid metabolites were compared between the two groups,and the difference of bile acids between the two groups was detected by establishing an orthogonal partial least squares discriminant analysis(OPLS-DA)model.The correlation between the difference of bile acids and sex hormones was analyzed.Results The levels of serum anti-mullerian hormone,luteinizing hormone,luteinizing hormone/follicle-stimulating hormone,testosterone(T)and dehydroepiandrosterone sulfate(DHEAS)in the PCOS group were higher than those of the control group(all P＜0.05).Compared with the control group,the levels of serum primary free bile acid chenodeoxycholic acid in PCOS group were increased(P＜0.05),while the levels of secondary conjugated bile acids glycodeoxycholic acid(GDCA)and glycolithocholic acid in PCOS group were decreased(both P＜0.05).The difference of bile acids between the two groups was found by OPLS-DA model as GDCA,and the correlation analysis showed that GDCA was negatively correlated with T and DHEAS(rs=-0.363,-0.342,respectively,both P＜0.05).Conclusion Patients with PCOS have bile acid metabolism disorder and abnormal sex hormone levels,and GDCA is closely related to hyperandrogenic symptoms of PCOS.
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