Expressions and clinical prognostic significance of PLAGL2 and SNX5 in hepatocellular cancer tissue
Objective To investigate the expressions of pleomorphic adenoma gene like protein 2(PLAGL2)and sorting nexin 5(SNX5)in hepatocellular cancer(HCC)and their clinical prognostic significance.Methods Ninety-two HCC patients diagnosed and treated in Xinzhou Hospital Affiliated to Shanxi Medical University from February 2019 to February 2020 were enrolled in the study.Immunohistochemistry was used to detect the expressions of PLAGL2 and SNX5 in HCC tissue and adjacent tissue samples.Kaplan-Meier survival curve was drawn,and the 3-year cumulative survival of patients with postive and negative expressions of PLAGL2 and SNX5 was compared using log-rank test.Univariate and multivariate Cox regression analysis was used to analyze independent risk factors for HCC prognosis.Results The positive rates of PLAGL2 and SNX5 in HCC cancer tissue were 78.26％(72/92)and 76.09％(70/92),respectively,which were higher than those in adjacent tissues[6.52％(6/92)and 4.35％(4/92),both P＜0.01].The positive rates of PLAGL2 and SNX5 in HCC patients with TNM stage Ⅲ and maximum tumor diameter＞5 cm were higher than those with TNM stages Ⅰ-Ⅱ and maximum tumor diameter ≤5 cm(all P＜0.05).The 3-year cumulative survival rate of the PLAGL2-positive patients was 51.39％(37/72),significantly lower than the 80.00％(16/20)of PLAGL2-negative patients(P=0.037).The 3-year cumulative survival rate of the SNX5-positive patients was 50.00％(35/70),also significantly lower than the 81.82％(18/22)of SNX5-negative patients(P=0.020).Maximum tumor diameter＞5 cm,TNM stage Ⅲ,postive expressions of PLAGL2 and SNX5 were independent risk factors for prognosis of HCC patients(all P＜0.01).Conclusion PLAGL2 and SNX5 positive rates increased in HCC tissues,both of which are involved in promoting the occurrence and development of HCC.Positive expressions of PLAGL2 and SNX5 are independent risk factors affecting the prognosis of HCC patients,and are potential prognostic tumor markers for HCC.
Hepatocellular cancerPleomorphic adenoma gene like protein 2Sorting nexin 5Prognosis
万方数据
维普
