High-frequency ultrasonography combined with serum calcitonin and carcinoembryonic antigen level in the diagnosis of medul-lary thyroid carcinoma
Objective To explore the value of high-frequency ultrasonography combined with serum calcitonin(CT)and carcinoembryonic antigen(CEA)examination in the diagnosis of medullary thyroid carcinoma(MTC).Methods Fifty-five patients with MTC confirmed by postoperative pathology in Liaocheng Second People's Hospital from January 2015 to February 2023 were enrolled as MTC group,while another 77 patients confirmed with benign thyroid tumors by postoperative pathology and treated in the same period were selected as non-MTC group.All patients underwent high-frequency ultrasonograpy before surgery,and serum CT and CEA were also examined.The sonographic characteristics and serum CT and CEA levels were compared between the two groups.The values of high-frequency ultrasonography,and serum examination used alone or in combination for diagnosing MTC were assessed,with the postoperative pathological diagnosis as the gold standard.Results There were no significant differences in anteroposterior/transverse diameter ratio and position of the high-frequency ultrasonic image between the MTC group and the non-MTC group(both P＞0.05),but significant differences were observed in composition,echo,margin,and calcification between the two groups(all P＜0.05).The sensitivity,specificity and accuracy in the diagnosis of MTC were 63.64％,70.13％and 67.42％respectively by high-frequency ultrasound,70.91％,72.73％and 71.97％respectively by serum CT and CEA levels,and 87.27％,88.31％and 87.88％respectively by combined examination.The sensitivity,specificity and accuracy of combined examination were all higher than those of high-frequency ultrasonography and serum examination(all P＜0.05).Conclusion Compared with benign thyroid tumors,MTC rarely has cystic changes,and its ultrasound images are more likely to be solid,hypoechoic,unsmooth margin,and combined with coarse calcification.The combination of high-frequency ultrasonography,and serum CT and CEA examination can significantly improve the diagnosis performance for MTC,compared with ultrasonography and serum examination used alone,which can guide the clinical selection of surgical plan more accurately.
万方数据
维普
