Diagnostic value of HINTS combined with serum IL-6 for cerebral infarction in patients with isolated vertigo
Objective To assess the diagnostic value of head impulse-nystagmus-test of skew(HINTS)combined with serum IL-6 for cerebral infarction in patients with isolated vertigo.Methods Ninety-one patients with isolated vertigo admitted in Qingdao Eighth People's Hospital from June 2022 to October 2023 were enrolled,including 23 cases of cerebral infarction and 68 cases of peripheral vertigo diagnosed according to clinical evaluation and brain MRI.Compare the general information and laboratory examination results of two groups of patients,perform HINTS bedside examination immediately upon admission,and make a preliminary diagnosis of cerebral infarction or peripheral vertigo based on the HINTS examination results.Compare this with the diagnosis made by clinical evaluation and cranial MRI examination.Use multivariate logistic regression analysis to identify risk factors for cerebral infarction in patients with isolated vertigo.Use ROC curves to evaluate the diagnostic efficacy of HINTS,serum IL-6,and the combination of HINTS and serum IL-6 for cerebral infarction in patients with isolated vertigo.Results In cerebral infarction group,the proportion of smoking,diabetes,hypertension,vertebro-basilar artery stenosis patients,and the level of FPG,IL-6 were higher than those of peripheral vertigo group(all P<0.05).Multivariate logistic regression analysis showed that high serum IL-6 level(OR=1.445,95%CI:1.016-2.054)was the risk factor for cerebral infarction in patients with isolated vertigo(P<0.05).The diagnostic sensitivity,specificity,positive predictive value,negative predictive value and accuracy of HINTS for cerebral infarction in patients with isolated vertigo was 0.826(95%CI:0.612-0.951),0.868(95%CI:0.764-0.938),0.679(95%CI:0.528-0.800),0.937(95%CI:0.858-0.973)and 0.857(95%CI:0.768-0.922),respectively.ROC curve analysis showed that the AUC of HINTS,serum IL-6 and HINTS combined with serum IL-6 to diagnose cerebral infarction in patients with isolated vertigo was 0.847,0.751 and 0.919,with a sensitivity of 0.826,0.696 and 0.826,a specificity of 0.868,0.735 and 0.897,respectively.Conclusion The combination of HINTS with serum IL-6 has a high diagnostic efficacy for cerebral infarction in patients with isolated vertigo.
Head impulse-nystagmus-test of skewIL-6VertigoCerebral infarction