Pathogenic distribution and risk factors of incision infection after cranioplasty
Objective To explore the clinical distribution and risk factors of incision infection after cranioplasty.Methods A total of 497 patients underwent cranioplasty in the Second Affiliated Hospital of Jiaxing University from January 2013 to December 2023,the clinical data of patients including gender,age,hypertension,diabetes,hormone use,hepatic insufficiency,renal insufficiency,hypoalbuminemia,serum prealbumin,causes of bone flap resection,preoperative level of consciousness,tracheotomy,time to cranioplasty,skin flap depression,defect site,large bone flap,preoperative hospital stay,repair materials,operation time,intraoperative meningeal injury,epidural effusion,urinary tract infection,pulmonary infection,admission to intensive care unit,bacterial distribution,drug resistance were retrospectively analyzed.Multivariate logistic regression was used to analyze the risk factors of incision infection after cranioplasty.Results Incision infection occurred after cranioplasty in 25 cases with an incidence rate of 5.0％.Bacterial culture was positive in 23 cases(92.0％),with a total of 26 strains.Accourding to bacterial culture,multidrug-resistant Staphylococcus aureus was the most common pathogen(13/26,50.0％).After intravenous antibiotics and subcutaneous injection of antibiotics,repair materials were successfully retained in 20 of the 25 cases,and no recurrence of infection was observed during the follow-up period of 0.5-3 years.Multivariate logistic regression analysis showed that skin flap depression and large bone flap were independent risk factors for incision infection after cranioplasty(P＜0.05).Conclusion Staphylococcus aureus is the most common pathogen of incision infection after cranioplasty with high proportion of multi-drug resistance.Patients with skin flap depression and large bone flap are likely to develop incisional infection after cranioplasty.
万方数据
维普
