Clinicopathological features of endometrioid endometrial carcinoma with microcystic,elongated,and fragmented(MELF)inva-sion pattern
Objective To investigate the clinicopathologic features of endometrioid endometrial carcinoma(EEC)with microcystic,elongated,and fragmented(MELF)invasion pattern.Methods Ninety patients with EEC admitted to Shaoxing Maternal and Child Health Care Hospital from January 2020 to March 2024 were retrospectively analyzed,including 13 cases of MELF invation pattern and 77 cases of non-MELF invation pattern.The clinicopathological features of the two groups were compared according to the staging criteria of the 2023 International Federation of Obstetrics and Gynecology(FIGO)for endometrial cancer,and the influencing factors of MELF invation pattern were analyzed.Results In MELF group,the proportion of patients with FIGO stage Ⅱ/Ⅲ and non-invasive histological type was higher;the micrometastasis and solitary tumor cells in pelvic lymph node metastasis were also higher.Patient with FIGO stage Ⅱ was 15.4％higher than it was evaluated by FIGO 2009 standard(2/13).Immunohistochemical staining showed that the tumor markers had different express states in EEC and MELF tissues.Compared with non-MELF group,the maximum diameter of lesion ≥2.0 cm,FIGO Ⅱ/Ⅲ stage,myometrium infiltration ≥1/2 layer,lymphatic vascular space infiltration(LVSI)and pelvic lymph node metastasis in MELF group were significantly higher.Multivariate logistic regression analysis showed that extensive LVSI was an independent influencing factor for MELF infiltration pattern(P＜0.05).Conclusion EEC with MELF invasion pattern is more likely to have lesions with maximum diameter ≥2.0 cm,FIGO Ⅱ/Ⅲ stage,myometrial infiltration ≥1/2 layer,LVSI and pelvic lymph node metastasis,among which extensive LVSI is an independent risk factor for MELF invasion pattern.
Endometrioid endometrial carcinomaMicrocystic elongated and fragmented(MELF)International Federation of Gynecology and Obsterics staging
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维普
