Expression of PD-L1 in triple-negative breast cancer and its clinicopathological significance
Objective To investigate the expression of programmed death ligand 1(PD-L1)in triple-negative breast cancer(TNBC),and to analyze its clinicopathological significance.Methods Seventy-seven TNBC tissue(TNBC group)and eighty non-TNBC tissue(non-TNBC group)admitted in the Second Hospital of Jiaxing between January 2017 and December 2019 were enrolled.The expression of PD-L1 in interstitial infiltrating immune cells of two groups were detected by immunochemical method,and the relationship of PD-L1 expression with clinicopathological features was analyzed.Results The expression rate of PD-L1 in TNBC group(40.3％)was significantly higher than that in non-TNBC group(16.3％)(P＜0.05).There were significant differences of expression of PD-L1 between histological grade,lymph node metastasis,Ki-67 expression and density of interstitial infiltrating immune cells in two groups(all P＜0.05).Conclusion The expression of PD-L1 in TNBC is significantly higher than that in non-TNBC.The expression of PD-L1 in TNBC is closely related to the clinicopathological characteristics of histological grade,lymph node metastasis,Ki-67 expression and density of interstitial infiltrating immune cells.
Triple-negative breast cancerInterstitial infiltration immune cellsImmunohistochemistryProgrammed cell death 1 ligand 1
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维普
