Analysis on drug-resistance status and risk factors in pulmonary tuberculosis patients in Beilun District,Ningbo City
Objective To clarify the drug-resistance status of tuberculosis patients in Beilun District,Ningbo,and to analyze the risk factors associated with drug-resistant tuberculosis,particularly multidrug-resistant tuberculosis. Methods A retrospective study was conducted involving 707 tuberculosis patients diagnosed and treated at Beilun District People's Hospital from January 2017 to December 2021. The drug-resistance status of these patients was analyzed. The occurrence rates of drug-resistant tuberculosis were compared among different groups based on sex,age,household registration,occupation,symptoms,tuberculosis history,diabetes history,and hypertension history. Multivariate logistic regression analysis was employed to identify the risk factors for multidrug-resistant tuberculosis. Results Mycobacterium tuberculosis was cultured from all 707 patients. Among them,576 were sensitive to first-line anti-tuberculosis drugs,while 131 were resistant,resulting in an overall drug resistance rate of 18.53％(131/707). The rates of mono-resistance,poly-resistance,and multidrug-resistance were 10.61％(75/707),3.25％(23/707),and 4.67％(33/707),respectively. The results of univariate analysis showed that the rates of multidrug-resistant in patients with a history of tuberculosis,a history of diabetes,and those whose time since the last anti-tuberculosis treatment was>2 years were respectively higher than those in patients without a history of tuberculosis,without a history of diabetes,and those whose time since the last anti-tuberculosis treatment was ≤ 2 years (all P<0.05). The rate of rifampicin resistance in patients whose time since the last anti-tuberculosis treatment was>2 years was higher than that in patients whose time since the last anti-tuberculosis treatment was ≤ 2 years (P<0.05). The rate of isoniazid resistance in patients with a history of hypertension was higher than that in patients without a history of hypertension (P<0.05). The rate of single resistance to streptomycin or ethambutol among patients engaged in commercial services was higher than that among patients of other occupations (P<0.05). Multivariate logistic regression analysis identified a history of tuberculosis as an independent risk factor for developing multidrug-resistance in tuberculosis patients (P<0.05). Conclusion The overall drug-resistance rate and multidrug-resistance rate of pulmonary tuberculosis patients in Beilun District from 2017 to 2021 are relatively low,indicating positive results in prevention and control of the disease. However,vigilance must still be maintained,and improving the success rate of initial treatment remains crucial.
万方数据
维普
