The 24 hour urine output,urine nitrite and quantitative count of urinary sediment bacteria for diagnosis of urinary tract infec-tion in patients with nephrotic syndrome
Objective To evaluate the application of 24 hour urinary protein(24 hUP)and the quantitative count of urine nitrite and urinary sediment bacteria for diagnosis of urinary tract infection(UTI)in patients with nephrotic syndrome(NS)complicated with.Methods A total of 380 NS patients admitted in Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine from October 2021 to October 2023 were enrolled,including 96 cases with UTI(infection group)and 284 cases without UTI(non-infection group).The clinical data,24 hUP,urinary nitrite levels,and the positive rate of quantitative bacterial count in urine sediment were compared between the two groups.The correlation among 24 hUP,urine nitrite levels and positive rate of quantitative bacterial count in urine sediment,was analyzed.The changes of above indicators were compared before and after treatment,and their diagnostic value was evaluated.Results The age and serum creatinine(Scr)levels in the infection group were higher,and the serum IgG level was lower than those in the non-infection group(both P＜0.05).The 24 hUP level,positive rate of urine nitrite,and positive rate of quantitative urine sediment bacterial count in the infection group were all higher than those in the non-infection group(all P＜0.05).The 24 hUP was positively correlated with urine nitrite and the positive rate of quantitative bacterial count in urine sediment in the infection group(rs=0.577,0.610,both P＜0.05).The positive rates of 24 hUP,urine nitrite,and the positive rate of quantitative bacterial count in urine sedirment in both groups were lower after treatment than those before treatment(all P＜0.05).The positive rates of UP,urine nitrite,and the positive rate of quantitative bacterial count in urine sediment in the infection group were higher than those in the non-infection group before and after treatment(all P＜0.05).The 24 hUP in the infection group was positively correlated with both urine nitrite levels and the positive rate of quantitative bacterial count in urine sediment in urine sediment(both P＜0.05).The logistic analysis showed that 24 hUP,urine nitrite,and the positive rate of quantitative bacterial count in urine sediment were independent factors affecting UTI in NS with(P＜0.05).The AUC of the combination of 24 hUP,urine nitrite,and the positive rate of quantitative bacterial count in urine sediment for diagnosis of UTI in NS patients was 0.926(95％CI:0.894-0.950),which was significantly higher than that of each indicator alone.Conclusion In NS patients complicated with UTI,the increase in 24 hUP is positively correlated with urine nitrite and quantitative bacterial count of urine sediment;the combination of the three indicators may be used to diagnose UTI in NS patients.
Nephrotic syndromeUrinary tract infection24 hour urinary protein levelUrine nitriteQuantitative counting of bacteria in urine sediment
万方数据
维普
