Serum HMGB1,TNF-α and HSP70 levels in predicting major adverse cardiovascular events in patients after percutaneous coronary intervention
Objective To invesgate the value of serum high mobility group protein B1(HMGB1),TNF-α and heat shock protein 70(HSP70)levels in predicting major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 104 patients with acute STEMI admitted to Hangzhou Hospital of Traditional Chinese Medicine from May 2019 to May 2022 were included.All patients received PCI treatment and were followed up for 6 months after surgery.Based on whether the patients experienced MACE(including death,postoperative angina,ventricular tachycardia,ventricular fibrillation),patients were divided into MACE group(n=41)and non-MACE group(n=63).The clinical data and serum levels of blood urea nitrogen(BUN),serum creatinine(Scr),TC,TG,HMGB1,TNF-α,and HSP70 were compared between two groups.The risk factors of MACE in STEMI patients after PCI were analyzed with multivariate logistic regression analysis.The value of serum HMGB1,TNF-α and HSP70 levels for predicting MACE in STEMI patients after PCI was analyzed with ROC curve.Results MACE group had a higher proportion of patients aged ≥ 60 years,with the culprit vessel being the right coronary artery,and higher levels of serum HMGB1,TNF-α,and HSP70 than the non-MACE group(all P＜0.05).Multivariate logistic regression analysis showed that age≥60 years,the culprit vessel being the right coronary artery,high levels of serum HMGB1,TNF-α,and HSP70 were independent risk factors for MACE in STEMI patients after PCI(all P＜0.05).The ROC curve showed that the AUC of HMGB1,TNF-α,and HSP70 for predicting MACE in STEMI patients after PCI were 0.796,0.884,and 0.911,respectively(all P＜0.05).Conclusion Elevated serum levels of HMGB1,TNF-α,and HSP70 are risk factors for MACE in STEMI patients after PCI,and clinical physicians should closely monitor the abnormal changes in these indicators.
万方数据
维普
