Mendelian randomization analysis on the association between physical activity and stress urinary incontinence
Objective To explore the causal relationship between physical activity and stress urinary incontinence (SUI) by two-sample and multivariable Mendelian randomization (MR) analysis.Methods Single nucleotide polymorphisms strongly associated with "job involving heavy physical work" "job involving mainly walking or standing" "duration of vigorous activity" and "duration of moderate activity" were chosen as instrumental variables,and SUI was selected as the outcome variable.The genome-wide association data on exposure and outcome were obtained from the Genome-Wide Association Studies database.Two-sample MR analysis was carried out using the inverse-variance weighted (IVW) method,and the result was verified by sensitivity analysis respectively.Results IVW analysis showed a possible positive causal relationship between job involving mainly walking or standing (OR=1.004,95％CI:1.002-1.006,P=0.001),duration of vigorous activity (OR=1.004,95％CI:1.001-1.008,P=0.018) and SUI,while job involving heavy physical work and duration of moderate activity had no association with SUI risk.The sensitivity analysis indicated that the conclusion was robust,and the MR-Egger method showed no pleiotropy.Multivariable MR analysis results showed that the causal association remained statistically significant (both P<0.01).Conclusion Maintaining a certain intensity of physical exercise for a long time or engaging in a job that requires long walking or standing may increase the risk of SUI.
万方数据
维普
