Predictive value of NLR,PLR and HPV infection status for prognosis of patients with stage Ⅱ-Ⅲ cervical squamous cell carcinoma following radiotherapy and chemotherapy
Objective To investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and HPV infection status for the prognosis of patients with stage Ⅱ-Ⅲ cervical squamous cell carcinoma (CSCC) following radiotherapy and chemotherapy.Methods Clinical and pathological data of 113 patients with stage Ⅱ-Ⅲ CSCC who underwent radiotherapy and chemotherapy in the Affiliated Cancer Hospital of Xinjiang Medical University from January 2017 to December 2019 were retrospectively analyzed.ROC curve was drawn to analyze the diagnostic efficacy of NLR and PLR for prognosis,optimal cut-off values for both was determined and grouped them.The clinical pathological characteristics and survival differences between high and low NLR group,high and low PLR group,HPV infected and uninfected group patients were also compared.Multivariate Cox regression analysis was used to identify the influence factors that affect patient prognosis.Results The AUC of NLR and PLR for predicting patient prognosis were 0.757 (95％CI:0.665-0.849) and 0.677 (95％CI:0.569-0.786),with the best cut-off values of 2.20 and 135.37,respectively.There were statistically significant differences in age and tumor diameter between the high and the low NLR group (both P<0.05);the age difference between the high and the low PLR group (P<0.05);There was no statistically significant difference in clinical data between the HPV infection and uninfection group (all P>0.05).The 5-year overall survival (OS) rate and 5-year progression free survival (PFS) rate were significantly different between patients with high and low NLR group,high and low PLR group,and HPV infection and uninfection group (all P<0.05).The OS of patients was dignificantly associated with age,differentiation degree,tumor stage,HPV infection,NLR and PLR;the PFS of patients was significantly associated with age,tumor stage,HPV infection,NLR and PLR (all P<0.05).Multivariate Cox regression analysis showed that higher tumor stage,NLR>2.20,and HPV infection were independent predictive factors for OS and PFS in stage Ⅱ-Ⅲ SCC patients after radiotherapy and chemotherapy (both P<0.05).Conclusion High NLR,high PLR,and HPV infection are unfavorable indicators for the prognosis of stage Ⅱ-Ⅲ SCC patients.
Cervical squamous cell carcinomaNeutrophile to lymphocyte ratioPlatelets lymphocyte ratioHPVPrognosis
万方数据
维普
